Switzerland - Japan Workshop
New Directions in Cellular and Tissue
Biomechanics
Les Diablerets, Switzerland
September 24-28, 2001
Sponsored by：
Swiss National Science Foundation
Japan Society for the Promotion of Science
Organized by：
Swiss Federal Institute of Technology - Lausanne
Japan Society of Mechanical Engineers, Division of Bioengineering
Scientific Committee
Switzerland:
Andreas Engel
Biozentrum, University of Basel
Ernst Hunziker
M.E. Muller Institute for Biomechanics, University of Bern
Peter Niederer
Institute of Biomedical Engineering - Swiss Federal
Institute of Technology, Zurich
Jean-Jacques Meister (co-chair)
Biomedical Engineering Laboratory - Swiss Federal
Institute of Technology, Lausanne
Japan:
Toshiaki Hara
Faculty of Engineering, Niigata University
Kozaburo Hayashi (co-chair)
Graduate School of Engineering Science, Osaka University
Masaaki Sato
Graduate School of Engineering, Tohoku University
Kazuo Tanishita
Faculty of Science and Technology, Keio University
Secretariat
For any information, please contact:
Biomedical Engineering Laboratory
Swiss Federal Institute of Technology
Attn to Yvette Ga11ay
PSE - Ecublens
1015 Lausanne
Tel: +41 21 693 83 45
Fax: +41 21 693 83 05
E-mail: yvette.gallay@epfl.ch
Scientific Program
Vascular Biomechanics: September 25, 8:30 -
12:30
Chair: M. Sato and P. Niederer
8:30
Karino T. (Hokkaido University), Wada S., Naiki T.
"Flow-dependent concentration polarization of
lipoproteins" as a localizing mechanism of vascular diseases
9:10
Stergiopulos N. (Swiss Federal Institute of Technology,
Lausanne)
Biomechanics of arterial remodeling: from basic science
to applied vascular technologies
9:50 - 10:10
Coffee break
10:10
Hayashi K. (Osaka University), Makino A., Kakoi D.,
Miyazaki H.
Arterial wall remodeling developed by blood flow and
blood flow changes
10:30
Matsumoto T. (Tohoku University), Sato M.
Theoretical and experimental analysis of stress and
strain distribution in the artery wall having material inhomogeneity
10:50
Beny J.-L. (Geneva University)
Information networks in the arterial wall
11:10
Ogasawara Y. (Kawasaki Medical School), Kajita T.,
Matsumoto T., Kajiya F.
Spatial correlation of mitochondrial redox state and
microcirculatory flow distribution in beating rat heart
11:30
Tsujioka K. (Kawasaki Medical School), Asahara H.
Effect of local blood flow condition on production of
nitric oxide by vascular endothelial cell and expression of eNOS
11:50
Quarteroni A. (Swiss Federal Institute of Technology,
Lausanne)
Multiscale models for the simulation of vascular flow
12:10
Yamaguchi T. (Nagoya Institute of Technology), Mori D.,
Hayasaka T.
Development of a patient specific modeling system for
clinical cardiovascular flow-wall interaction studies
12:30-14:00
Lunch
New Areas in Biomechanics I: September 25,
14:00 - 18:20
Chair: M. Sokabe and E. Hunziker
14:00
Yanagida T. (Osaka University)
Single molecule dynamics and mechanics
14:40
Engel A. (Basel University)
Imaging and manipulating membrane proteins using the
atomic force microscope
15:20
Wada H. (Tohoku University)
Psychological characteristics of our hearing are mainly
determined by the motility of sensory cells
16:00- 16:20
Coffee break
16:20
Verkhovsky A. (Swiss Federal Institute of Technology,
Lausanne)
Moving cells: what moves, when and where
17:00
Danuser G. (Swiss Federal Institute of Technology,
Zurich)
Cell shape and motility is controlled by actin flow
dynamics
17:40
Keller H. (Bern University)
Mechanisms of protrusion and locomotion
Cellular Biomechanics: September 26, 8:30 -
12:30
Chair: K. Tsujioka and A. Engel
8:30
Kamiya A. (Nihon University)
System physiology of oxygen transport and related
cellular biomechanics
9:10
Sokabe M. (Nagoya University)
Mechanotransduction in endothelial cells: SA channel, integrin
and cytoskeleton
9:50 - 10:10
Coffee break
10:10
Meister J.-J. (Swiss Federal Institute of Technology,
Lausanne)
Mechanical properties of endothelial cell cytoplasm and
nucleus
10:30
Ando J. (University of Tokyo)
Calcium signaling of fluid shear stress in vascular
endothelial cells
10:50
Sato M. (Tohoku University), Sakamoto N., Ohashi T.,
Iwano A.
Effect of O2/CO2 gas condition on
calcium and morphological responses of cultured endothelial cells to shear
stress
11:10
Tanishita K. (Keio University)
Enhance macro-molecule transport due to the shear stress
stimulus
11:30
Bochaton-Piallat M.-L. (Geneva University)
Role of smooth muscle cell in atheromatosis and
restenosis
11:50
Quinn T. (Orthopedic Hospital and Swiss Federal Institute
of Technology, Lausanne)
Relationship between mechanical compression, solute
transport, and cell metabolism in cartilage: potential applications
to tissue engineering
12:10
Adachi T. (Kobe University), Sato K., Tomita Y.
Calcium signaling response in osteoblastic cells to
mechanical stimulus by micropipette
12:30-14:00
Lunch
New Areas in Biomechanics II: September 27,
8:30 - 12:10
Chair: K. Tanishita and G. Danuser
8：30
Kajiya F. (Okayama University）
Application of synchrotron radiation（Spring-8）to cardiovascular
biomechanics
9：10
Margaritondo G. (Swiss Federal Institute of Technology,
Lausanne)
Synchrotron light in molecular biology; from
characterization to nanofabrication
9：50-10:10
Coffee break
10：10
Martin I. (Basel University)
Mechanobiology and biomechanics of tissue engineered
cartilage
10：50
Ushida T. (University of Tokyo), Tateishi T．
Physical stimulation to chondrocytes for
tissue-engineered cartilage regeneration
11：30
Kucera P. (Lausanne University)
Spatial and temporal organization of enteric pacemakers
12:30-14:00
Lunch
Orthopedic Biomechanics, September 27, 14：00-18：00
Chair: T. Hara and T. Quinn
14：00
Hunziker E. (Bern University）
The potential of the synovium for cartilage repair
14：40
Tanaka E. (Nagoya University), Yamamoto S.
A mathematical model of bone remodeling process
15：20
Niederer P. (Swiss Federal Institute of Technology，Zurich)
Micromechanics of minor cervical spine injuries
16:00 - 16:20
Coffee break
16：20
Zysset P. (Swiss Federal Institute of Technology,
Lausanne)
Morphological and mechanical properties of bone
structural units
16：40
Takakuda K. (Tokyo Medical and Dental University),
Matsumoto H.，Kanaya T., Koyama T.,
Miyairi H.
Adaptive remodeling of bone under mechanical stimuli
17：00
Tanaka M. (Osaka University), Todoh M., Ebara S.
Computation analysis of idiopathic scoliosis： A viewpoint of inconsistent growth
between hard and soft tissue components
17：20
Murakami T. (Kyushu University), Sawae Y., Ihara M.
The protective mechanism of articular cartilage to severe
loading：Roles of lubricants,
Cartilage surface layer, extracellular matrix and chondrocyte
17：40
Yasui T. (Osaka University), Nakamoto K., Tohno Y., Araki
T.
Laser induced dynamic emission sensitive to the
conformation of tissue collagen
Commented poster session, September 28, 8:30 -
10:10
Chair: T. Murakami and N. Stergiopulos
Cellular Biomechanics
8：30
Sugawara M. (Tohoku University), Wada H.
Elastic properties of lateral wall and force production
of the outer hair cell: Theoretical consideration
8：34
Kataoka N. (Kawasaki Medical School), Ogasawara Y.,
Tsujioka K., Kajiya F.
Monocyte adhesion induces the change of the mechanical
properties of endothelial cells measured with an atomic force microscope
8：38
Kurata K. (Kyushu University and University of Turku),
Uemura T., Nemoto A., Tateishi T., Murakami T., Higaki H., Miura H., Iwamoto Y.
Mechanical strain enhances bone-resorbing activity and
mRNA expressions of marker enzymes in highly enriched osteoclast culture
8：42
Miyazaki H. (Osaka University), Hasegawa Y., Hayashi K.
Tensile properties of synthetic and contractile
phenotypes of vascular smooth muscle cells
8：46
Dehghani Zadeth A. (Bern University)
The role of surface glycoproteins (CD43, CD45) and
cytoskeletal components in the development of PMN polarity
8：50
Laurent V. (Swiss Federal Institute of Technology.
Lausanne)
Partitioning the cytoskeleton mechanical response into
cytosolic and cortical compartments: concept, experimental validation and
preliminary applications
8：54
Ponti A. (Swiss Federal Institute of Technology, Zurich),
Danuser G.
Actin flow dynamics measured by fluorescence speckle
microscopy
8：58
Hao H. (University of Geneva)
Phenotypic heterogeneity of arterial smooth muscle cells
9：02
Yamada H. (Kyushu Institute of Technology), Takemasa T.,
Yamaguchi T.
Numerical simulation of the orientation of cultured cells
and intracellular stress fibers under cyclic stretch: Prediction of substrate
deformation from orientation data
Vascular biomechanics
9：06
Kato Y. (Tohoku University & Riken), Mastumoto T.,
Kumagai K., Akimoto H., Tabayashi K., Sato M.
Construction of three-dimensional finite element models
of thoracic aortic aneurysms and stress analysis in the aortic walls
9:10
Formaggia L. (Swiss Federal Institute of Technology, Lausanne)
Wave propagation in arteries with the presence of
prosthesis
9：14
Zulliger M. (Swiss Federal Institute of Technology,
Laussannee）
Short-term in vitro adaptation of porcine carotid artery
elastic module to high and low transmural pressures
9：18
Zunino P. (Swiss Federal Institute of Technology，Lausanne)
Computational modeling of mass transport in the arterial
wall
9：22
Kobayashi S. (Shinshu University), Horie T., Morikawa H.,
Tang D., Ku D. N.
Hemodynamics and wall compression in high grade
asymmetric arterial stenoses
Orthopedic Biomechanics
9:26
Tsubota K. (Kobe University and Riken), Adachi T., Tomita
Y.
Simulation study on trabecular surface remodeling using
digital image-based model
9:30
Yamamoto S. (Nagoya University), Tanaka E., Harada A.,
Mizuno M.
Evaluation of mechanical and morphological factors of hip
fracture
9:34
Park Y. D. (Bern University)
Preparation and characterization of bioactive hyaluronic
acid based hydrogel
9:38
Sugimoto M. (Bern University)
Gene expression of synoviocytes in 3D culture
9:42
Buechler P. (Orthopedic Hospital and Swiss Federal
Institute of Technology, Lausanne)
Humeral head design: Biomechanical comparison of two
prostheses
9:46
Koseki M. (Tokyo Institute of Technology), Inou N., Maki
K.
Individual stress analysis of the human mandible under a
biting condition
9:50
Morita Y. (Kyoto University), Tomita N., Aoki H.,
Wakitani S., Tamada Y., Harada Y., Suguro T., Ikeuchi K.
Visco-elastic properties of regenerated cartilage tissue
using fibroin sponge
9:54
Pioletti D. (Orthopedic Hospital and Swiss Federal
Institute of Technology, Lausanne)
Orthopaedic implant as drug delivery system
Others
9:58
Koike T. (Tohoku University), Wada H., Kobayashi T.
Sound transmission characteristics of human and guinea
pig middle ears: A finite-element method analysis
10:02
Dorri F. (Swiss Federal Institute of Technology, Zurich)
Fiber Orientation and fiber forces in the human
myocardium
10:04
Bertrand D. (University of Geneva), Renaud P.
Strain gauges for ocular pressure monitoring