バイオエンジニアリング部門
メーリングリスト登録者各位

　　　　　　　　　　　　　　　　　　　　　　　　　　　　主査　大橋　俊朗

下記の要領にて第44回「計測と力学-生体への応用」研究会（共催）を開催いた
します．
多数のご参加をお待ちしております．なお，本研究会は日本機械学会北海道支部
バイオメカニクス
懇話会第15回講演会および北海道大学大学院工学研究院人間機械システムデザイ
ン部門特別講演会の
共催として開催いたします．

----------------------------------　記　--------------------------------
　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
2014年1月25日

　　　　　　　　　　　日本機械学会北海道支部　バイオメカニクス懇話会
　　　　　　　　　　　　　　　　　　第15回講演会
　　　　　　　　　北海道大学大学院工学研究院人間機械システムデザイン部門
　　　　　　　　　　　　　　　　　　　特別講演会
（共催：日本機械学会北海道支部，日本機械学会バイオエンジニアリング部門
「計測と力学
　　　　-生体への応用-」研究会）
　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　主査
　大橋　俊朗

下記の要領にて第15回講演会を開催いたします．本講演会は日本機械学会北海道
支部特別講演会，
日本機械学会バイオエンジニアリング部門第44回「計測と力学-生体への応用-」
研究会と共催
いたします．また，第１講演は北海道大学大学院工学研究院人間機械システムデ
ザイン部門の
特別講演会の主催といたします．
多数のご参加をお待ちしております． 
　　　
　　　　　　　　　　　　　　　　　　　　　　記

日　時：2014年2月6日（木），15:00～17:00
場　所：北海道大学大学院工学研究院・工学部　大会議室A1-17室
　　　　http://www.eng.hokudai.ac.jp/building/?place=outer
講　演：
15:00～16:00
Speaker: Prof. Taiji Adachi (Kyoto University, Japan)
Title: Structural Optimality in Bone: Modeling Osteocyte Network as a 
Mechanosensory System
Abstract: Ever since Julius Wolff proposed the Law of Bone 
Transformation in the 19th century, it has been widely accepted that the 
bone structure adapts function￢ally to the mechanical environment. 
There seems to be a mathematical correspondence between bone structure 
and stress trajectories as if trabecular/osteonal bone remodels toward 
its optimal structure. However, the mechanism by which bone remodels its 
microstructure to meet macro￢scopic functional demands as a load-
bearing structure is not clear, because of the complex hierarchical 
system from molecular/cellular to tissue/organ levels with a variety of 
mechano-biochemical couplings. The process of bone remodeling is 
regulated by cellular activities. While osteoclasts and osteoblasts are 
responsible for bone resorption and formation, respectively, activities 
of these cells are believed to be controlled by a mechanosensory system 
of osteocytes embedded in the bone matrix. Under dynamic loading, the 
bone matrix deformation induces fluid flow in the lacuno-canalicular 
system that stimulates the osteocyte process membrane. In addition, 
intercellular network in the system may serve as a pathway to deliver 
mechanical signals to neighboring cells regulating their remodeling 
activities. Therefore, in this study, focusing on osteocyte mech￢
anosensing and communication, we discuss how macroscopic well-organized 
bone structure is formed from microscopic cellular activities, based on 
multiscale modeling and simulation.

16:00～17:00
Speaker: Prof. Peter Vee Sin Lee (The University of Melbourne, Australia)
Title: Using A Hierarchical Approach to Investigate Cartilage and 
Subchondral Bone Responses Under Impact Load
Abstract: Osteoarthritis (OA) is a condition affecting the joints, and 
is a leading cause of chronic pain and disability worldwide. OA leads to 
cartilage and bone damage and is still not clearly understood. It is 
well known that micro damage in bone or cartilage due to impact load can 
trigger bone remodelling. In the repair process, bone resorption and 
bone formation are closely coupled and well balance. In the OA joint, 
imbalance can cause articular cartilage thinning. Any attempt to halt 
the progression of OA through physical rehabilitation or drug therapies, 
or reparative surgery using new implant materials, will require 
quantitative knowledge of bone and cartilage micro structure. Our 
overall focus is therefore to understand the structural integrity of 
cartilage and bone. We have developed multi-scale techniques to apply 
physiological loads on cartilage and bone via human motion experiments 
and mechanical testing systems. Damage to the cartilage and bone was 
studied using high resolution imaging techniques. In addition, 
computation models were used to probe the load bearing abilities of 
cartilage/bone affected by OA, to help advance our understanding of the 
disease process.


問い合わせ先：
大橋　俊朗　北海道大学大学院工学研究院人間機械システムデザイン部門

------------------------------(in English)------------------------------
　　　　　　　　　　                                                     
                  January 24, 2014

　　　　　　　　　　　The Japan Society of Mechanical Engineers
　　　　　　　　　　　　　　　　Hokkaido Branch
　　　　　　　　　　　　“Biomechanics Research Meeting”
　　　　　　　　　　　　　　　　　15th Seminar
　　　　　　　　　Division of Human Mechanical Systems and Design
　　　　　　　　　　　　　Graduate School of Engineering
　　　　　　　　　　　　　　　　Hokkaido University
　　　　　　　　　　　　　　　　　Special Seminar

(Cosponsored by Hokkaido branch, The Japan Society of Mechanical 
Engineers; “Instrumentation 
and Mechanics - Application to Living Bodies -” technical sections, 
Bioengineering division, 
The Japan Society of Mechanical Engineers)
　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
Chairman: Toshiro Ohashi

The Biomechanics Research Meeting and Division of Human Mechanical 
Systems and 
Design will (co)sponsor presentations by distinguished scientists, Prof. 
Taiji Adachi 
from Kyoto University, Japan and Prof. Peter Vee Sin Lee from The 
University of Melbourne,
Australia. Faculty members, graduate students, and undergraduates are 
encouraged to 
participate in the seminar. 

Date&Time: February 6, 2014, 15:00 - 17:00
Place: Room#A1-17, Faculty of Engineering, Hokkaido University
          http://www.eng.hokudai.ac.jp/building/?place=outer

15:00 - 16:00
Speaker: Prof. Taiji Adachi (Kyoto University, Japan)
Title: Structural Optimality in Bone: Modeling Osteocyte Network as a 
Mechanosensory System
Abstract: Ever since Julius Wolff proposed the Law of Bone 
Transformation in the 19th century, it has been widely accepted that the 
bone structure adapts function￢ally to the mechanical environment. 
There seems to be a mathematical correspondence between bone structure 
and stress trajectories as if trabecular/osteonal bone remodels toward 
its optimal structure. However, the mechanism by which bone remodels its 
microstructure to meet macro￢scopic functional demands as a load-
bearing structure is not clear, because of the complex hierarchical 
system from molecular/cellular to tissue/organ levels with a variety of 
mechano-biochemical couplings. The process of bone remodeling is 
regulated by cellular activities. While osteoclasts and osteoblasts are 
responsible for bone resorption and formation, respectively, activities 
of these cells are believed to be controlled by a mechanosensory system 
of osteocytes embedded in the bone matrix. Under dynamic loading, the 
bone matrix deformation induces fluid flow in the lacuno-canalicular 
system that stimulates the osteocyte process membrane. In addition, 
intercellular network in the system may serve as a pathway to deliver 
mechanical signals to neighboring cells regulating their remodeling 
activities. Therefore, in this study, focusing on osteocyte mech￢
anosensing and communication, we discuss how macroscopic well-organized 
bone structure is formed from microscopic cellular activities, based on 
multiscale modeling and simulation.

16:00 - 17:00
Speaker: Prof. Peter Vee Sin Lee (The University of Melbourne, Australia)
Title: Using A Hierarchical Approach to Investigate Cartilage and 
Subchondral Bone Responses Under Impact Load
Abstract: Osteoarthritis (OA) is a condition affecting the joints, and 
is a leading cause of chronic pain and disability worldwide. OA leads to 
cartilage and bone damage and is still not clearly understood. It is 
well known that micro damage in bone or cartilage due to impact load can 
trigger bone remodelling. In the repair process, bone resorption and 
bone formation are closely coupled and well balance. In the OA joint, 
imbalance can cause articular cartilage thinning. Any attempt to halt 
the progression of OA through physical rehabilitation or drug therapies, 
or reparative surgery using new implant materials, will require 
quantitative knowledge of bone and cartilage micro structure. Our 
overall focus is therefore to understand the structural integrity of 
cartilage and bone. We have developed multi-scale techniques to apply 
physiological loads on cartilage and bone via human motion experiments 
and mechanical testing systems. Damage to the cartilage and bone was 
studied using high resolution imaging techniques. In addition, 
computation models were used to probe the load bearing abilities of 
cartilage/bone affected by OA, to help advance our understanding of the 
disease process.

Contact:
Toshiro Ohashi
Division of Human Mechanical Systems and Design, Faculty of Engineering, 
Hokkaido University
------------------------------------------------------------------------