2015年7月14日

バイオエンジニアリング部門
メーリングリスト登録者各位
　　　　　　　　　　　　　　　　　　　日本機械学会 A-TS 02-09
　　　　　　　　　　　　　研究会主査　和田　成生（大阪大学）

バイオエンジニアリング部門研究会「生物機械システム研究会」
第４３回研究会を下記の要領にて開催致します．御多用とは存じ
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　　　　　　　　　　　記

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　　　　第４３回生物機械システム研究会
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【日時】2015年7月27日（月）16:30〜18:30
【場所】大阪大学大学院基礎工学研究科　シグマホール
　　　　（大阪府豊中市待兼山町 1-3）
　　　　　http://www.es.osaka-u.ac.jp/en/access.html

【プログラム】
演題1：16:30-17:25
Pulmonary acinar biomechanics -kinematics and particle deposition in
pulmonary acinus-

講演者：
Toshihiro Sera, Associate Professor
Department of Mechanical Engineering, Faculty of Engineering,
Kyusyu University

概要：
Pulmonary acinus is constituted the groups of structures peripheral
to terminal bronchiole, including alveolar ducts and numerous
surrounding alveoli, and is defined functionally as the largest lung
unit. The acinus expands and contracts in volume during breathing.
The varying three dimensional complicated geometry is fundamental
to the study of alveolar mechanics and can affect acinar biomechanics,
such as acinar flow and particle deposition. Here, I present our recent
works on acinar kinematics and particle deposition in acinus. For acinar
kinematics, we observed acinar deformation of mice lungs in situ during
quasi-static inflation and deflation using synchrotron CT. For particle
deposition, we reconstructed the complicated acinar geometry based
on synchrotron CT images and evaluated the distribution of nano- and
micro-particle deposition using computational fluid dynamics.


演題2：17:40-18:30
Pulmonary acinar particle transport: convection, sedimentation,
diffusion and their interplay

講演者：
Philipp Hofemeier and Josue Sznitman, Technion, Israel Institute of
Technology

概要：
Inhaled fine and ultrafine aerosols can either pose a health risk, e.g.
sooty particles, or can be integral particle of medical treatments
serving as drug carriers with the potential to further migrate into
the systemic circulation. To date, it is widely acknowledged that
inhaled particles ranging from 0:001 to 10 m are able to reach and
deposit in the alveolated regions of the lungs. However, little is known
about the local transport dynamics and deposition mechanisms of
(ultra) fine particles affected by diffusion, convection and
sedimentation. Using computational fluid dynamics (CFD) simulations,
we shed some light on the local transport characteristics of inhaled
aerosols in the acinar region and analyze physiologically-relevant
deposition metrics.
    
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【問合先】
研究会幹事：田原大輔　datawara@rins.ryukoku.ac.jp
　　　　　　龍谷大学理工学部機械システム工学科