バイオエンジニアリング部門
メーリングリスト登録者各位
　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
いつもお世話になっております．
下記の要領にて第51回「計測と力学-生体への応用」研究会（共催）を開催いた
します．
なお，本研究会は日本機械学会北海道支部バイオメカニクス懇話会第23回講演 
会（主催）および
日本生体医工学会専門別研究会「バイオメカニクス研究会」第160回研究会 
（共催）として開催いたします．
多数の皆様のご参加をお待ちしております．

主査　大橋　俊朗

-----------------------------------　記　-------------------------------
　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　 
　　　　　　2015年11月17日

　　　　日本機械学会バイオエンジニアリング部門「計測と力学―生体への
応用―」
　　　　　　　　　　　　　　　　　　第51回研究会

主　催：日本機械学会北海道支部バイオメカニクス懇話会
共　催：日本機械学会北海道支部，日本生体医工学会専門別研究会「バイオメ 
カニクス研究会」
　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　 　　　　 
　　　　　　　主査　大橋　俊朗

下記の要領にて第51回「計測と力学-生体への応用」研究会（共催）を開催いた
します．
多数の皆様のご参加をお待ちしております．

日　時：2016年6月24日（金），11:00〜12:00
場　所：北海道大学大学院工学研究院・工学部　大会議室A1-17室
	http://www.eng.hokudai.ac.jp/building/?place=outer
講　演：
「Magnetic nanoparticles for new therapies and diagnosis」
Prof. M. Ricardo Ibarra
Director, Instituto de Nanociencia de Arag溶 (INA) Universidad de 
Zaragoza, Spain
Professor, Laboratorio de Microscopias Avanzadas (LMA) Universidad de 
Zaragoza, Spain

Magnetic nanoparticles (MNPs) constitute nowadays a vast field of 
research due to the current and expected application in 
nanobiomedicine. The potential MNPs stems from the intrinsic 
properties of their magnetic cores, combined with the functionality 
acquired under an appropriate coating. The capability for loading and 
targeted controlled release of drugs is one of the main issues in 
cancer therapy (for recent reviews see [1,2]). The 
biofunctionalization of the nanoparticles surface make them suitable 
for magnetic separation based on the biomolecular recognition of 
biological moieties. New inmunomagnetic assays using magnetic 
nanoparticles provides a new route to quantize the results in 
biosensors. The presence of MNPs also perturb locally the hydrogen 
proton relaxation, this phenomenon is on the bases of the enhance MRI 
diagnostic using contrast agents. Targeting of these contrast agents 
could detect angiogenesis processes at early stages.
In this talk a brief review of all these different applications will 
be depicted emphasizing the application of electromagnetic waves in 
new therapies based on magnetic hyperthermia. The case of dendritic 
cells (DCs) as main candidate for magnetic hyperthermia will be 
reported. Magnetic hyperthermia (MH) is based on the use of MNPs to 
selectively increase the temperature of MNP-loaded target tissues 
when applying an alternating magnetic field (AMF) in the range of 
radiofrequency. To date, all MH research has focused on heat 
generation in an attempt to elucidate the mechanisms for the death of 
MNP-loaded cells submitted to AMF. However, recent in vitro studies 
have demonstrated the feasibility of inducing dramatic cell death 
without increasing the macroscopic temperature during AMF exposure. 
Here, we show that the cell death observed following AMF exposure, 
specifically that of MNPs loaded dendritic cells (DCs) in culture, 
was caused by the release of toxic agents into the cell culture 
supernatants and not due to a macroscopic temperature increase.[3] We 
performed MH in vitro experiments to demonstrate that the supernatant 
of the cell culture following AMF exposure was highly toxic when 
added to control unloaded DCs, as this treatment led to nearly 100% 
cell death. Therefore, our results demonstrate that heat is not the 
only agent responsible for triggering cell death following MH 
treatment. This finding offers new perspectives for the use of DCs as 
the proverbial Trojan horse to vectorise MNPs to the target tumour 
area and these results further support the use of DCs as therapeutic 
agents against cancer when submitted to AMF. Furthermore, this 
discovery may help in understanding the mechanism of cell death 
mediated by exposure to AMF.

[1] “Magnetic nanoparticles for drug delivery” M. Arruebo, R. 
Fernandez-Pacheco, M.R. Ibarra and J. Santamar誕. Nanotoday 2 (2007) 
22, [2] “Magnetic nanoparticles for cancer therapy” G.F: Goya, V. 
Grazu and M.R. Ibarra. Current Nanoscience 4  (2008) 1-16, [3] 
“Induced cell toxicity originates dendritic cell death following 
magnetic hyperthermia treatment”  L As地,  G F Goya,  A Tres &  M R 
Ibarra. Cell Death and Disease 4, e596 doi:10.1038/cddis.2013.121 
(http://www.nature.com/cddis)

問い合わせ先：
大橋　俊朗　　北海道大学大学院工学研究院人間機械システムデザイン部門
Tel&Fax: 011-706-6424, Email: ohashi@eng.hokudai.ac.jp
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大橋　俊朗（Toshiro Ohashi）
北海道大学大学院工学研究院人間機械システムデザイン部門
〒060-8628　札幌市北区北13条西8丁目
Tel/Fax: 011-706-6424
E-mail: ohashi@eng.hokudai.ac.jp
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