バイオエンジニアリング部門
メーリングリスト登録者各位
　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
いつもお世話になっております．
下記の要領にて第56回「計測と力学-生体への応用」研究会（共催）を開催いた
します．
なお，本研究会は日本機械学会北海道支部バイオメカニクス懇話会第28回講演会
（主催）および
日本機械学会北海道支部特別講演会 （共催）として開催いたします．
多数の皆様のご参加をお待ちしております．

「計測と力学-生体への応用」研究会
主査　大橋　俊朗

-----------------------------------　記　-------------------------------
　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
2017年6月29日

　　　　　　　　　　　日本機械学会北海道支部　バイオメカニクス懇話会
　　　　　　　　　　　　　　　　　　第28回講演会

（共催：日本機械学会北海道支部，日本機械学会バイオエンジニアリング部門
「計測と力学
　　　　?生体への応用?」研究会）

　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　        　
　　主査　大橋　俊朗

下記の要領にて第28回講演会を開催いたします．本講演会は日本機械学会北海道
支部特別講演会，
日本機械学会バイオエンジニアリング部門第56回「計測と力学-生体への応用-」
研究会と共催と
いたします．多数のご参加をお待ちしております．

日　時：2017年7月7日（金），16:30-18:00
場　所：北海道大学大学院工学研究院・工学部　アカデミックラウンジ3
	http://www.eng.hokudai.ac.jp/building/?place=outer
講　演：
16:30-17:15
「Mechanical Responses of Cultured Endothelial Cells in View of Spatial Shear Stress Gradient」
Prof. Masaaki Sato
Professor, Director of Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Japan

Arterial bifurcations are known to be common sites for development of cerebral aneurysms, where the combination of high shear stress (SS) and high spatial SS gradient (SSG) may induce some damages or dysfunction of endothelial cells (EC). However, the details of the relationship between the hemodynamic environment and EC responses remain unclear. We have developed two types of flow chamber to apply simultaneously SS and SSG to ECs. One is T-shaped flow section in a chamber and the flow velocity and SSG are not constant depending on the location. 
The other is designed to be SSG constant in the some flow section.
Confluent ECs were exposed to various levels of SS and SSG for 24 h using both flow chambers. 
Although ECs exposed to lower levels of SS/SSG were not oriented or elongated in the direction of flow, they responded under the conditions of SS with an SSG when the SS exceeded a threshold value depending on the magnitude of SSG. Using a simplified computational model, we found that the presence of an SSG affects the strain field in ECs, resulting in a morphological response. 
SS combined with an SSG can alter the localization of SS mechano-sensing proteins along the strain field as a result of shear flow. The results suggest that the magnitude of the relationship between SS and SSG plays an important role in regulating EC polarity and the resulting morphological changes in response to fluid flow.

17:15-18:00
「Bioengineering Strategies to Minimize Damage of Vulnerable Skin Tissue」
Prof. Dan Bader
Professor, Faculty of Health Sciences, University of Southampton, UK and Department of Biomedical Engineering, Eindhoven University of Technology, the Netherlands

A few researchers have adopted an hierarchical approach, involving multi -scale models, to examine various aspects of soft tissue damage, in the form of pressure ulcers ( PUs). These have identified several physiological mechanisms each of which play a role in concert in the aetio-pathogenesis of PUs. These include, mechanical-induced ischaemia, ischaemia- reperfusion injury, impaired lymphatic and interstitial fluid flows and direct cell damage. 
Translation to human models involves
 monitoring conditions at the loaded soft tissue interface and developing early screening methods to identify individuals at risk of developing PUs. A recent focus involves the potential damage caused by medical devices, designed to support functional activities in patients with vulnerable tissues. Devices include respiratory masks in both paediatric and adult intensive care units, the prosthetic socket-stump interface of amputees, as well as support surfaces associated with sitting and lying. The experimental approach adopts both biomechanical (pressure and shear) and microclimate (temperature and humidity) measures, and the use of biomarkers to assess the skin response to mechanical-induced irritation caused by prolonged use of medical devices. 
The resulting parameters can provide input in the form of boundary conditions at the device-skin interface into computational models to predict conditions at which soft tissue damage can occur. 

問い合わせ先：
大橋　俊朗　　北海道大学大学院工学研究院人間機械システムデザイン部門
Tel&Fax: 011-706-6424, Email: ohashi@eng.hokudai.ac.jp
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大橋　俊朗（Toshiro Ohashi）
北海道大学大学院工学研究院人間機械システムデザイン部門
〒060-8628　札幌市北区北13条西8丁目
Tel/Fax: 011-706-6424
E-mail: ohashi@eng.hokudai.ac.jp
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