2019年4月20日

バイオエンジニアリング部門
メーリングリスト登録者各位
                                                                日本機械学会 A-TS02-09
                                         研究会主査　出口 真次（大阪大学）

バイオエンジニアリング部門研究会「生物機械システム研究会」
第51回研究会を下記の要領にて開催いたします．御多用とは存じ
ますが，万障お繰り合わせのうえ，ご出席いただきますよう，
よろしくお願い申し上げます．

                                        記

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　　　第51回生物機械システム研究会
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日時：5月7日（火）15:30-17:10
場所：大阪大学 豊中キャンパス 基礎工学国際棟セミナー室
（右記リンク先の21番　 https://www.osaka-u.ac.jp/en/access/toyonaka ）

講演者：
- Amin Doostmohammadi博士 (Rudolf Peierls Centre for Theoretical Physics, University of Oxford, UK)
- Kennedy Omondi Okeyo博士 (京都大学 ウイルス・再生医科学研究所)

題目1：Cellular Active Fluids (Doostmohammadi博士) / 15:30-16:30
概要1：Monolayers of cells in tissue and bacterial colonies growing on substrates are ample 
examples of materials that are continuously driven out of equilibrium by the activity of 
their constituent elements. One generic property of these active materials is the spontaneous 
emergence of collective flows which often leads to chaotic flow patterns characterised by 
swirls, jets, and topological defects in their orientation field. In this talk I will discuss 
recent works on cell monolayers and growing bacterial colonies, where we find interesting 
correlations between liquid crystal-like features of these active systems and their biological 
functionality.
References:
[1] A. Doostmohammadi, et al., Active nematics. Nature Communications, 9:3246, 2018.
[2] A. Doostmohammadi, S. Thampi, J. M. Yeomans, Defect-mediated morphologies in growing cell 
colonies. Physical Review Letters, 117: 048102, 2016.
[3] T. B. Saw, A. Doostmohammadi, et al., Topological defects in epithelia govern cell death 
and extrusion. Nature, 544.7649: 212-216, 2017.

題目2：Mechanobiology of self-assembly and differentiation by stem cells under restricted 
adhesion condition (Okeyo博士) / 16:30-17:10
概要2：Stem cells, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) 
possess unlimited ability to expand under culture, and to differentiate into virtually all human 
cell types, making them invaluable biological resources with enormous application potential in 
medicine, basic studies and drug development. This talk will highlight our ongoing work aimed at 
understanding the mechanobiology of self-assembly and differentiation of stem cells in which we 
employ microfabrication techniques to modulate the stem cell culture microenvironment so as to 
unlock their differentiation and self-organization potentials. Specifically, we will introduce 
our original technique, namely, the micromesh technique, which enables us to modulate the balance
 between cell-cell and cell-substrate adhesions in order to influence tissue mechanics resulting
 from self-organization and differentiation of stem cells. We will demonstrate the potential of 
this approach to mechanically trigger trophoblast-like differentiation and primordial germ 
cell-like differentiation patterns in human iPSCs and murine ESCs, respectively. 


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【照会先】
研究会幹事：大友涼子　otomo@kansai-u.ac.jp
　　　　　　関西大学システム理工学部機械工学科