バイオエンジニアリング部門 メーリングリスト登録者各位                                     いつもお世話になっております. 下記の要領にて第61 回,第62回「計測と力学-生体への応用」研究会(共催) を開催いたします. なお,本研究会は日本機械学会北海道支部バイオメカニクス懇話会(主催), および日本機械学会 北海道支部特別講演会 (共催)として開催いたします. 皆様のご参加をお待ちしております. 「計測と力学-生体への応用」研究会 主査 大橋 俊朗 -------------------------------- 記 ----------------------------                                                  2019年6月23日            日本機械学会北海道支部 バイオメカニクス懇話会                   第35回講演会 (共催:日本機械学会北海道支部,日本機械学会バイオエンジニアリング部門 「計測と力学-生体への 応用-」研究会)                                      主査 大橋 俊朗  下記の要領にて第35回講演会を開催いたします.本講演会は日本機械学会北 海道支部特別講演会, 日本機械学会バイオエンジニアリング部門第61回「計測と力学-生体への応用 -」研究会と共催いたします. 皆様のご参加をお待ちしております.                        記 日 時:2019年7月2日(火),16:00〜17:30 場 所:北海道大学大学院工学研究院・工学部 A6-63室 http://www.eng.hokudai.ac.jp/building/?place=outer 講 演: 16:00〜16:45 「Study of keratin from Mongolian camel hair and goat cashmere for biocompatible materials」 Prof. Ganbat Danaa Mongolian University of Science and Technology (MUST), Mongolia Keratin, a fibrous structural protein, that is available from a constituent of Mongolian animals, is a potential candidate for the fabrication of scaffolds for tissue engineering. While several sources of keratin can be considered, the bioactivity of the keratins obtained can be different. In this study we discuss the processing, and characterization of keratin from camel hair and goat cashmere. The camel hair and cashmere were dissolved in an ionic liquid, and the characteristics of the soluble and unsoluble keratin were evaluated. The structure and properties of the raw material, soluble and unsoluble keratin were studied. Compared to the starting material, the soluble keratin showed chemical changes, decrease of cysteine, and minor structural changes. Preliminary in vitro biological properties performed by a lactate dehydrogenase (LDH) assay and scratch test showed good bioactivity in keratin from both sources. In particular, cell migration was observed to be faster when cells were cultured in the presence of soluble keratin extracted from camel hair and cashmere. 16:45〜17:30 「Engineering limbs: Helping amputees walk in Vietnam」 Prof. Peter Lee The University of Melbourne, Australia Over 25 million people in the world need prosthetic orthotic devices, many of whom come from developing countries where access to specialised personnel and services is a major challenge. Demand for artificial limbs is even more urgent in countries where land mines from wars are still prevalent. Professor Peter Lee from the Department of Biomedical Engineering at the University of Melbourne, will discuss his biomechanical engineering research in developing low -cost artificial limbs, using the Pressure Cast (PCAST) technique, a portable and easy to use prosthetic socket fitting system that requires less technical skill and labour to administer. He will also discuss his experience working with patients and clinics in Vietnam to implement PCAST. 問い合わせ先: 大橋 俊朗  北海道大学大学院工学研究院人間機械システムデザイン部門 Tel&Fax: 011-706-6424, Email: ohashi@eng.hokudai.ac.jp ---------------------------------------------------------------- -------------------------------- 記 ----------------------------                                                  2019年6月23日            日本機械学会北海道支部 バイオメカニクス懇話会                   第36回講演会 (共催:日本機械学会北海道支部,日本機械学会バイオエンジニアリング部門 「計測と力学-生体への 応用-」研究会)                                      主査 大橋 俊朗  下記の要領にて第36回講演会を開催いたします.本講演会は日本機械学会北 海道支部特別講演会, 日本機械学会バイオエンジニアリング部門第62回「計測と力学-生体への応用 -」研究会と共催いたします. 皆様のご参加をお待ちしております.                        記 日 時:2019年7月4日(木),16:00〜17:30 場 所:北海道大学大学院工学研究院・工学部 大会議室A1-17室 http://www.eng.hokudai.ac.jp/building/?place=outer 講 演: 16:00〜16:45 「Complex Adaptive Cancer Immunotherapy」 Prof. In-San Kim Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Korea/KU-KIST Graduate School of Converging Science and Technology, Korea University, Korea Immunotherapy is revolutionizing the treatment of cancer. The current immunotherapeutics that work by taking the brakes off T cells have been particularly transformational, dramatically improving outcomes for some cancer patients. But we still need to answer to those patients whose cancers do not respond to these immunotherapeutics, and those whose cancers respond initially but then become resistant to the t reatments. The more we study the major issues of tumors, the more we come to realize that they cannot be understood in isolation. Tumors are systemic problems, which mean that they are interconnected and interdependent. Cancer cells are present within a complex adaptive ecosystem consisted of associated cells including immune cells, connective tissue cells, endothelial cells within a scaffold of matrix altogether forming tumor microenvironment. Cancer, perhaps uniquely among human illnesses, is a disease that arises through Darwinian interactions of microenvironmental selection and phenotypic adaptation, which are both causes and consequences of its complexity and heterogeneity. Since a life has begun 3.5 billion years ago, they ensured continuous interaction between the diverse species, both cooperative and fiercely competitive in nature. So they have developed complex and sophisticated immune system to survive. Can we develop better systems to fight against cancer than our own immune system? Even though we do not understand completely our own immune systems, we could try at least to awaken our own immune system to fight against cancer. In an attempt to trigger our own immunity against cancers, we utilized the characteristic of genetic instability to our advantage, as the expression of cancer cell neoantigens triggers immunity against cancer cells, which can be called “intrinsic cancer vaccination”. For this purpose, we designed protein nanocages or extracellular vesicles (exosomes), which hold not only ligands for enhancing cancer cell phagocytosis but also drugs for inducing immunogenic cancer cell death. This strategy will allow us to avoid using known tumor specific antigens, ex vivo manipulation and adoptive cell therapy, instead, efficiently present neoantigens of cancer cells to our immune system. This strategy could be combined with other treatment modalities to potentiate the therapeutic efficacy. 16:45〜17:30 「H-TRAIN : Hongreung Biomedical Cluster」 Prof. Kuiwon Choi Principal Investigator, H-TRAIN Program, Korean Institute of Science and Technology (KIST), Korea H-TRAIN Program is a translational research program developed in 2018. The purpose of the program is to facilitate commercialization of the biomedical technologies developed in KIST. This program is originated from Translational Research Center (TRC) Program in KIST since 2012, then updated and renamed as H-TRAIN. Hongreung is the area where the origin of Korean R&D since 1966 when KIST was developed. KAIST has once also been located in this area, although KASIT moved to other city in late 1980's. Around this area there exist more than 10 universities, 2 major university hospitals, 2 specialized government hospitals and 3 government- sponsored research institutes including KIST. Approximately 5,000 ph.D.s are working in this area. Recently, Seoul city developed the Seoul Bio-hub in this area to promote industrialization of biomedical technologies as an accelerating organization. For now, there are more than 30 start-ups are under incubation and more start-ups will be accommodated soon. In Korea, the biomedical area is now considered as one of main future growth engine of Korean economy. Thus a lot of efforts both from the Government and local governments has been put into this area. The role of GRIs becomes more emphasized and the industrialization of the biomedical technologies is essential to the future of Korea. This is why H-TRAIN was born in KIST. In this presentation, I will introduce the H-TRAIN program along with the future of Hongreung Biomedcal Cluster. 問い合わせ先: 大橋 俊朗  北海道大学大学院工学研究院人間機械システムデザイン部門 Tel&Fax: 011-706-6424, Email: ohashi@eng.hokudai.ac.jp ---------------------------------------------------------------------- -- ************************************************** 大橋 俊朗(Toshiro Ohashi) 北海道大学大学院工学研究院人間機械システムデザイン部門 〒060-8628 札幌市北区北13条西8丁目 Tel/Fax: 011-706-6424 E-mail: ohashi@eng.hokudai.ac.jp **************************************************