Chair: Ryo Sudo (Keio University, Japan)
17:00 – 18:00 Keynote Lecture:
“Building Perfusable Microvascular Models for Tissue Regeneration and Disease Modeling”
Ying Zheng (University of Washington, USA)
慶應義塾大学 矢上キャンパス 14棟2階 セミナールーム3（14-203）
慶應義塾大学 理工学部システムデザイン工学科／須藤亮／E-mail: email@example.com
京都大学 医生物学研究所／牧功一郎／E-mail: firstname.lastname@example.org
JSME Bioengineering Division
Biofrontier Seminar 2023
17:00-18:00 December 14, 2023
Keio University, Japan
Ying Zheng, PhD
Department of Bioengineering, University of Washington
Building perfusable microvascular models for tissue regeneration and disease modeling
Microvasculature is an immense organ that defines the environmental conditions within tissues in both health and disease and is vital for the proper functioning of all tissues. Hence, proper microvascular structure and function are critical in engineered tissue for regeneration and modeling diseases. Numerous models have emerged in the past decade to recapitulate complex microvascular structure, either by cellular self-assembly or by directly engineering and patterning, and to study the role of cellular, biophysical and biochemical factors on microvascular remodeling. In this talk, I will present our approach to building perfusable microvascular models that allow for precise control of initial vascular geometry, cellular composition, hemodynamics, and extracellular matrices. I will also present our effort in building organ-specific (i.e. kidney and brain) microvascular structures and functions to study vascular inflammation and their role in disease onset and progression. I will discuss the perspectives of incorporating spatiotemporal control in future microvascular models to advance the understanding of tissue injury and regeneration.
Ying Zheng, Ph.D. received her BS degree from University of Science and Technology of China (USTC) in 2002 and Ph.D. degree in Biomedical Engineering of University of Michigan, Ann Arbor (2008). After she graduated, Dr. Zheng worked as a postdoctoral research associate with Prof. Abe Stroock at Cornell University. She joined UW Bioengineering in 2011 as a faculty and is now an Associate Professor in the Department of Bioengineering. Her research focuses on understanding and building fundamental structure and functions in living tissue and organ system. Selective awards include American Heart Association Scientist Development Award and NIH Director’s New Innovator Award.